It all sticks together—the APP-related family of proteins and Alzheimer's disease
نویسندگان
چکیده
منابع مشابه
Physiological functions of APP family proteins.
Biochemical and genetic evidence establishes a central role of the amyloid precursor protein (APP) in Alzheimer disease (AD) pathogenesis. Biochemically, deposition of the β-amyloid (Aβ) peptides produced from proteolytic processing of APP forms the defining pathological hallmark of AD; genetically, both point mutations and duplications of wild-type APP are linked to a subset of early onset of ...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 1999
ISSN: 1359-4184,1476-5578
DOI: 10.1038/sj.mp.4000552